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Long acting inhaled beta-2 agonist bronchodilators Long acting inhaled beta-2 agonist bronchodilators such as salmeterol (Serevent) and formoterol are chemically related to intervention bronchodilators such as albuterol and pirbuterol but can last 12 hours.

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Effect of long-term corticosteroid use on bone mineral density in children: A prospective longitudinal assessment in the childhood Asthma Management Program (CAMP) study.

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Such asthma severity level could change over years or months.

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No cases of fulminant hepatitis or chronic liver injury have been convincingly linked to use of these agents.

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If optimal asthma control cannot be achieved on moderate doses of ICS, then escalation of therapy by the addition of LTRA represents an acceptable step (Evidence A).

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